John McLean
Vanderbilt Center for Innovative Technology (CIT)
Our research focuses on the design, construction, and application of advanced technologies for structural mass spectrometry, in particular, for studies in systems, synthetic, and chemical biology. We primarily focus on the comprehensive, untargeted, and rapid characterization of molecules directly from complex biological samples, generating signals for 10,000 to 100,000 molecules in approximately 1 minute. We utilize high performance deep learning tools to rapidly let the data inform us what is important about the sample system under investigation. These tools are then applied to a variety of biological systems with funding from the Department of Defense, the National Institutes of Health, the Environmental Protection Agency, and the Intelligence Advanced Research Project Agency.
Our research focuses on the design, construction, and application of advanced technologies for structural mass spectrometry, in particular, for studies in systems, synthetic, and chemical biology. We primarily focus on the comprehensive, untargeted, and rapid characterization of molecules directly from complex biological samples, generating signals for 10,000 to 100,000 molecules in approximately 1 minute. We utilize high performance deep learning tools to rapidly let the data inform us what is important about the sample system under investigation. These tools are then applied to a variety of biological systems with funding from the Department of Defense, the National Institutes of Health, the Environmental Protection Agency, and the Intelligence Advanced Research Project Agency.
Keywords: Analytical chemistry , mass spectrometry , molecular analysis , metabolomics , data science
Research Area: Computational and Systems Biology , Chemical Biology , Proteomics/Metabolomics