Lars Plate
Department of Chemistry
Department of Biological Sciences
Vanderbilt Institute of Chemical Biology (VICB)
Vanderbilt Institute for Infection, Immunology and Inflammation (VI4)
Chemical and Physical Biology Program (CPB)
Our research uses multidisciplinary approaches in chemical biology and proteomics to profile transient protein complexes. The goal is to understand how protein-protein interaction networks are dynamically regulated in diverse cellular processes, such protein folding and secretion, or during viral infections. We leverage new insights on the dysregulation of protein interactions networks in disease states to guide the development of therapeutic strategies.
Our research uses multidisciplinary approaches in chemical biology and proteomics to profile transient protein complexes. The goal is to understand how protein-protein interaction networks are dynamically regulated in diverse cellular processes, such protein folding and secretion, or during viral infections. We leverage new insights on the dysregulation of protein interactions networks in disease states to guide the development of therapeutic strategies.
Keywords: Protein Interaction Networks , Proteomics/Mass Spectrometry , Protein Misfolding Diseases , Host-Virus Interactions , Protein Quality Control , Chemical Biology
Research Area: Biophysics , Drug Design , Computational and Systems Biology , Host-Pathogen Interactions , Virology , Chemical Biology , Proteomics/Metabolomics