MacRae Linton
Department of Medicine
Division of Cardiovascular Medicine
Department of Pharmacology
Vanderbilt Genetics Institute (VGI)
Vanderbilt Diabetes Research and Training Center (DRTC)
Vanderbilt Vascular Biology Center (VVBC)
Vanderbilt Mouse Metabolic Phenotyping Center (VMMPC)
Atherosclerosis Research Unit
The Linton laboratory pursues basic science and clinical translational investigations of inherited disorders of lipoprotein metabolism, macrophage biology, and atherosclerosis. Dr. Linton pioneered the use of bone marrow transplantation (BMT) as an approach to investigate the impact of genes expressed by bone marrow-derived cells, including macrophages, on the development of atherosclerosis in murine models. A major area of interest is the role of HDL function in human disease. We also are actively involved in clinical cardiovascular outcome trials of lipid lowering drugs, including a recent gene therapy study in familial hypercholesterolemia.
The Linton laboratory pursues basic science and clinical translational investigations of inherited disorders of lipoprotein metabolism, macrophage biology, and atherosclerosis. Dr. Linton pioneered the use of bone marrow transplantation (BMT) as an approach to investigate the impact of genes expressed by bone marrow-derived cells, including macrophages, on the development of atherosclerosis in murine models. A major area of interest is the role of HDL function in human disease. We also are actively involved in clinical cardiovascular outcome trials of lipid lowering drugs, including a recent gene therapy study in familial hypercholesterolemia.
Keywords: Atherosclerosis , Lipoprotein metabolism , Macrophages , HDL , genetics of lipoprotein disorders , gene therapy
Research Area: Diabetes, Obesity, Metabolism , Cardiovascular Biology , Vascular Biology