Mary Philip
Department of Medicine
Division of Hematology and Oncology
Vanderbilt Institute for Infection, Immunology and Inflammation (VI4)
Vanderbilt-Ingram Cancer Center (VICC)
Department of Pathology, Microbiology and Immunology (PMI)
Program in Cancer Biology
The Philip Lab seeks to understand how the immune system interacts with developing cancers from the first mutation initiating carcinogenesis through progression to late-stage and metastatic tumors. We use clinically-relevant genetic cancer mouse models to understand the molecular and epigenetic regulatory mechanisms underlying tumor-specific T cell dysfunction and to design and test cutting-edge strategies to override T cell dysfunction to improve cancer immunotherapy.
The Philip Lab seeks to understand how the immune system interacts with developing cancers from the first mutation initiating carcinogenesis through progression to late-stage and metastatic tumors. We use clinically-relevant genetic cancer mouse models to understand the molecular and epigenetic regulatory mechanisms underlying tumor-specific T cell dysfunction and to design and test cutting-edge strategies to override T cell dysfunction to improve cancer immunotherapy.
Keywords: tumor immunology , T cells , epigenetics , carcinogenesis , gene-editing , reprogramming
Research Area: Gene Regulation , Immunology , Cancer Biology , Cancer Immunology , Molecular Pathology