Maulik Patel
Department of Biological Sciences
Department of Cell and Developmental Biology (CDB)
Vanderbilt Diabetes Research and Training Center (DRTC)
Disease can be defined as a state in which the body’s ability to maintain homeostasis of molecular and cellular processes within their physiologically “normal” range is compromised. We use state of the art approaches including genomics, high resolution imaging, and systems biology to study mitochondrial homeostasis. Our short-term is to provide fundamental insights into mechanisms of mitochondrial homeostasis and the consequences of its breakdown, while our long-term goal is to provide an evolutionary framework for understanding why and under what physiological circumstances mitochondrial homeostasis collapses.
Disease can be defined as a state in which the body’s ability to maintain homeostasis of molecular and cellular processes within their physiologically “normal” range is compromised. We use state of the art approaches including genomics, high resolution imaging, and systems biology to study mitochondrial homeostasis. Our short-term is to provide fundamental insights into mechanisms of mitochondrial homeostasis and the consequences of its breakdown, while our long-term goal is to provide an evolutionary framework for understanding why and under what physiological circumstances mitochondrial homeostasis collapses.
Keywords: genetics , development , reproduction , metabolism , mitochondria , stress , cell biology , systems biology
Research Area: Diabetes, Obesity, Metabolism , Host-Pathogen Interactions , Cell Cycle, DNA Repair, and Chromosome Biology , Genomics , Cell Signaling , Evolution , Cell Cycle, DNA Repair, and Chromosome Biology , Cell Structure , Computational and Systems Biology , Developmental Biology , Developmental Neuroscience , Gene Regulation , Imaging , Neurodegeneration & Neuroinflammation , Proteomics/Metabolomics , RNA Biology , Stem Cell Biology & Regeneration