Richard O’Brien
Vanderbilt Diabetes Research and Training Center (DRTC)
Department of Molecular Physiology and Biophysics (MPB)
Beta Cell Interest Group (BIG)
Metabolism Interest Group
Our lab is interested in two proteins, G6PC2 and ZnT8, that when mutated reduce the risk of type 2 diabetes in humans. We are working to understand the function of these proteins in vivo and we are developing inhibitors that target these proteins as novel therapies to prevent type 2 diabetes.
Our lab is interested in two proteins, G6PC2 and ZnT8, that when mutated reduce the risk of type 2 diabetes in humans. We are working to understand the function of these proteins in vivo and we are developing inhibitors that target these proteins as novel therapies to prevent type 2 diabetes.
Keywords: Diabetes , Insulin , Obesity , ZnT8 zinc transporter , G6pc2 glucose-6-phosphatase
Research Area: Diabetes, Obesity, Metabolism , Cell Signaling