Vito Quaranta
Vanderbilt Quantitative Systems Biology Center (QSBC)
NCI Center for Systems Biology of Small Cell Lung Cancer at Vanderbilt
Department of Biochemistry
Department of Pharmacology
Chemical and Physical Biology Program (CPB)
Program in Cancer Biology
Vanderbilt Institute of Chemical Biology (VICB)
The Quaranta laboratory combines theory and experimentation to understand cancer as a complex system, capable of evolving by a variety of genetic and non-genetic means in order to adapt to and evade treatment. The laboratory is comprised of a mix of experimentalists, engineers, statisticians, and mathematicians iteratively combining experimental and modeling tools towards a systems-level understanding of the basic principles governing cancer, with a specific focus on melanoma, lung and breast cancer. The Quaranta laboratory has made key contributions to developing single-cell methodologies that merge automated time-lapse microscopy with image analysis and computational modeling, in order to evaluate the dynamics of cancer cell response to targeted therapy.
Use Systems Biology approaches to examine heterogeneity in Cancer and its implications in therapy.
Keywords: Cancer Systems Biology , Drug Synergy , Epigenetic Landscape , Phenotypic heterogeneity and state transitions , Clonal evolution , Anti-cancer therapy , Single-cell
Research Area: Computational and Systems Biology , Gene Regulation , Cancer Biology , Genomics , RNA Biology