Vsevolod Gurevich
Department of Pharmacology
Neuroscience Graduate Program (NGP)
Department of Ophthalmology and Visual Sciences
Vanderbilt Institute of Chemical Biology (VICB)
Vanderbilt Brain Institute (VBI)
Vanderbilt Diabetes Research and Training Center (DRTC)
We study structure and biological functions of arrestin proteins. Arrestins are key regulators of G protein-coupled receptor signaling and several receptor-independent pathways that affect life and death of cells. Our ultimate goal is to create designer arrestins that bind the receptors we want and activate the pathways of our choosing.
We study structure and biological functions of arrestin proteins. Arrestins are key regulators of G protein-coupled receptor signaling and several receptor-independent pathways that affect life and death of cells. Our ultimate goal is to create designer arrestins that bind the receptors we want and activate the pathways of our choosing.
Keywords: arrestin , structure , G protein-coupled receptors , cell signaling , cell proliferation , cell death
Research Area: Structural Biology , Drug Design , Cell Signaling , Visual Sciences , Neurodegeneration and Neuroinflamation