Skip to main content

Chemical and Physical Biology Program

Mesocorticolimbic hemodynamic response in Parkinson's disease patients with compulsive behaviors.

AUTHORS

Claassen DO , Stark AJ , Spears CA , Petersen KJ , van Wouwe NC , Kessler RM , Zald DH , Donahue MJ , . Movement disorders : official journal of the Movement Disorder Society. 2017 6 19; ().

ABSTRACT

PD patients treated with dopamine therapy can develop maladaptive impulsive and compulsive behaviors, manifesting as repetitive participation in reward-driven activities. This behavioral phenotype implicates aberrant mesocorticolimbic network function, a concept supported by past literature. However, no study has investigated the acute hemodynamic response to dopamine agonists in this subpopulation.

PD patients treated with dopamine therapy can develop maladaptive impulsive and compulsive behaviors, manifesting as repetitive participation in reward-driven activities. This behavioral phenotype implicates aberrant mesocorticolimbic network function, a concept supported by past literature. However, no study has investigated the acute hemodynamic response to dopamine agonists in this subpopulation.