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Thank you for visiting the internet home of the Chemical and Physical Biology (CPB) graduate program at Vanderbilt University. The CPB program fosters education and training at the interface of the chemical sciences, physical sciences, and biology. The course work and research components of the program prepare students for research careers in which they are able to bring state-of-the-art tools of the modern chemical and physical sciences, mathematics, engineering, and computing to bear on cutting-edge problems in biology and medicine. The CPB program was founded by Drs. Al Beth and Hassane Mchaourab in 2007.

The program encompasses four tracks: Chemical Biology, Structural Biology and Molecular Biophysics, Systems Biology, and Imaging Science. Each track has a curriculum of core classes that provide students with foundational knowledge in that discipline, as well as elective offerings that serve to tailor and customize each student’s curriculum.  Each track is directed by a senior member of the Vanderbilt faculty and is associated with one or more research centers and institutional training grants. To help you learn more about the CPB program, please explore the rest of our site and contact the program leadership with questions.


Bruce Damon, PhD  Program Director

Recent Publications and  Findings from Our Students

Oviatt AA et al. Polyamine-containing etoposide derivatives as poisons of human type II topoisomerases: Differential effects on topoisomerase II? and II?. Bioorg Med Chem Lett. 2018 Sep 15; 28(17): 2961?2968.
Cao Z, Hutchison JM, Sanders CR, Bowie JU. Backbone Hydrogen Bond Strengths Can Vary Widely in Transmembrane Helices. Journal of the American Chemical Society. 2017;139(31):10742-10749. doi:10.1021/jacs.7b04819.
Perreault AA, Benton ML, Koury MJ, Brandt SJ, Venters BJ. Epo reprograms the epigenome of erythroid cells. Experimental hematology. 2017;51:47-62. doi:10.1016/j.exphem.2017.03.004.
Holt ME, Salay LE, O’brien E, Barton JK, Chazin WJ. Functional and structural similarity of human DNA primase [4Fe4S] cluster domain constructs. PLoSONE. 2018;13(12):e0209345.
O’brien E, Salay LE, Epum EA, Friedman KL, Chazin WJ, Barton JK. Yeast require redox switching in DNA primase. Proc Natl Acad Sci USA. 2018;115(52):13186-13191.
Perry NA, Kaoud TS, Ortega OO, et al. Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification. Proc Natl Acad Sci USA. 2018;
Juttukonda MR,Franco G, Englot DJ, Lin YC, Petersen KJ,Trujillo P, Hedera P, Landman BA, Kang H, Donahue MJ, Konrad PE, Dawant BM, Claassen DO. White matter differences between essential tremor and Parkinson disease. Neurology. 2019 Jan 1;92(1):e30-e39
Juttukonda MR, Lee CA, Patel NJ, Davis LT, Waddle SL, Gindville MC, Pruthi S, Kassim AA, DeBaun MR, Donahue MJ, Jordan LC. Differential cerebral hemometabolic responses to blood transfusions in adults and children with sickle cell anemia. JMagn Reson Imaging. 2018;
Perry NA, Kaoud TS, Ortega OO, et al. Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification. Proc Natl Acad Sci USA. 2018;
Meyer CT, Wooten DJ, Paudel BB, et al. Quantifying Drug Combination Synergy along Potency and Efficacy Axes. Cell Syst. 2019;8(2):97-108.e16.
Trujillo P, Van wouwe NC, Lin YC, Stark AJ, Petersen KJ, et al. Dopamine effects on frontal cortical blood flow and motor inhibition in Parkinson’s disease. Cortex. 2019;115:99-111.