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Chemical and Physical Biology Program

AlphaFold2 predicts the inward-facing conformation of the multidrug transporter LmrP

AUTHORS

Del Alamo D , Govaerts C , Mchaourab HS , . Proteins. 2021 05 11; ().

ABSTRACT

As part of the CASP competition, the protein structure prediction algorithm AlphaFold2 generated multiple models of the proton/drug antiporter LmrP. Previous distance restraints from double electron-electron resonance spectroscopy, a technique which reports distance distributions between spin labels attached to proteins, suggest that one of the lower-ranked models may have captured a conformation that has so far eluded experimental structure determination.