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Chemical and Physical Biology Program

Preschool anxiety disorders predict different patterns of amygdala-prefrontal connectivity at school-age.

AUTHORS

Carpenter KL , Angold A , Chen NK , Copeland WE , Gaur P , Pelphrey K , Song AW , Egger HL , . PloS one. 2015 ; 10(1). e0116854

ABSTRACT

In this prospective, longitudinal study of young children, we examined whether a history of preschool generalized anxiety, separation anxiety, and/or social phobia is associated with amygdala-prefrontal dysregulation at school-age. As an exploratory analysis, we investigated whether distinct anxiety disorders differ in the patterns of this amygdala-prefrontal dysregulation.

In this prospective, longitudinal study of young children, we examined whether a history of preschool generalized anxiety, separation anxiety, and/or social phobia is associated with amygdala-prefrontal dysregulation at school-age. As an exploratory analysis, we investigated whether distinct anxiety disorders differ in the patterns of this amygdala-prefrontal dysregulation.