Jonathan Schoenecker lab
I study systemic changes in coagulation and fibrinolysis that occur following a traumatic injury and how these later affect tissue repair. The survival response to trauma, termed the acute phase response, can often rapidly consume circulating coagulation factors and regenerative enzymes in an effort to prevent bleeding and infection. As a result, trauma patients are at a high risk for both thrombosis and bleeding initially and poor tissue repair later on. My goal is to identify which elements of the acute phase response can be safely targeted to improve survival and tissue regeneration in patients following a traumatic injury.