Brian Wadzinski
Our research focuses on understanding the role of protein kinase/phosphatase modules in the control of normal cellular signaling. We are exploiting complementary biochemical, immunological, and genetic strategies to better understand the structure, function, and regulation of these signaling modules in normal biology and disease. More recently, we have taken advantage of the unique immune system of alpacas, and have incorporated a “bench to farm and back again” approach to target these key signaling proteins.
Our research focuses on understanding the role of protein kinase/phosphatase modules in the control of normal cellular signaling. We are exploiting complementary biochemical, immunological, and genetic strategies to better understand the structure, function, and regulation of these signaling modules in normal biology and disease. More recently, we have taken advantage of the unique immune system of alpacas, and have incorporated a “bench to farm and back again” approach to target these key signaling proteins.
Keywords: kinases , phosphatases , cell signaling , antibodies , nanobodies , alpacas
Research Area: Structural Biology , Molecular Pathology , Cell Signaling