Chris Wright
Department of Cell and Developmental Biology (CDB)
Program in Developmental Biology (PDB)
Vanderbilt Center for Stem Cell Biology (VCSCB)
Vanderbilt Diabetes Research and Training Center (DRTC)
Vanderbilt-Ingram Cancer Center (VICC)
Our long-term goal is to provide insight into the molecular, genetic and cell-biological mechanisms that coordinate development of complex organ systems, which has relevance to human congenital birth defects, and overt and cryptic susceptibilities to disease or inherited syndromes. All of these processes can be analyzed using either single-cell or bulk methods such as ATAC-Seq, single-molecule-FISH, epigenetic analysis, real-time/time-lapse video- and super-resolution microscopy, 3D tissue-clearing immunolabeling approaches, and many others.
Our long-term goal is to provide insight into the molecular, genetic and cell-biological mechanisms that coordinate development of complex organ systems, which has relevance to human congenital birth defects, and overt and cryptic susceptibilities to disease or inherited syndromes. All of these processes can be analyzed using either single-cell or bulk methods such as ATAC-Seq, single-molecule-FISH, epigenetic analysis, real-time/time-lapse video- and super-resolution microscopy, 3D tissue-clearing immunolabeling approaches, and many others.
Keywords: Gene regulatory networks , Epigenetic control , Endodermal Organogenesis , Pancreas , Genetic manipulation , single-cell analysis
Research Area: Diabetes, Obesity, Metabolism , Imaging , Stem Cell Biology & Regeneration , Genomics , Molecular Pathology , Developmental Biology