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Erica Tross

Fisk University

Ian G. Macara lab

The existence of stem cells in the mammary gland is controversial, but lineage tracing and transplantation assays have identified a cell population that behaves as unipotent basal progenitors in vivo, but gains multipotent potential in vitro. I  use this cell population that expresses a splice variant of the SH2 domain-containing 5'-inositol phosphatase (s-SHIP) to study cell plasticity and elucidate the gene signature that defines stemness in this population.