Erin Aho
University of Delaware
Bill Tansey lab
WDR5 is an epigentic and transcriptional regulator that has recently been proposed as a new anti-cancer therapeutic target. My thesis research focuses on defining the utility of novel WDR5 small molecule inhibitors, created in collaboration with the Fesik lab, in combatting cancer. Using Acute Myeloid Leukemia cells as a model system, I aim to gain a detailed understanding of the molecular mode of action of our WDR5 inhibitors and elucidate genetic vulnerabilities that can render cells sensitive to WDR5 inhibition.