Johns Hopkins University
Jim Patton and Tonia Rex labs
Suppression of ptbp1 has been shown to convert glia to neurons, thus aiding in the regeneration process. However, transcriptomic analysis showed no differential change in ptbp1 expression during regeneration, and its mechanism of action during regeneration is largely unknown. For my thesis, I am characterizing the precise mechanism as to how ptbp1 impacts regeneration in organisms both with endogenous regenerative potential (zebrafish) and those without (mice).