Heather Pua
Department of Pathology, Microbiology and Immunology (PMI)
Vanderbilt Center for Immunobiology (VCI)
Vanderbilt Institute for Infection, Immunology and Inflammation (VI4)
Extracellular Vesicle Interest Group
Inflammatory and autoinflammatory diseases have high morbidity, limited diagnostic specificity and suboptimal treatments. In the Pua lab, we study how non-coding RNAs (particularly microRNAs) regulate inflammatory programs to uncover novel molecular networks in immune disease. We investigate both the cell-intrinsic roles of these regulatory RNAs as well as how they are communicate signals between cells when secreted into the extracellular space using mouse models, cell culture systems, molecular biology and high throughput sequencing.
Inflammatory and autoinflammatory diseases have high morbidity, limited diagnostic specificity and suboptimal treatments. In the Pua lab, we study how non-coding RNAs (particularly microRNAs) regulate inflammatory programs to uncover novel molecular networks in immune disease. We investigate both the cell-intrinsic roles of these regulatory RNAs as well as how they are communicate signals between cells when secreted into the extracellular space using mouse models, cell culture systems, molecular biology and high throughput sequencing.
Keywords: immunology , miRNA , asthma , allergy , RNA , extracellular vesicles
Research Area: RNA Biology , Immunology , Cell Signaling