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James Held

Purdue University

Maulik Patel lab

Mitochondrial dysfunction results in the inability to produce enough energy to meet cellular demand. Defects in mitochondrial function have profound effects on aging and have been associated with a growing list of diseases including a variety of metabolic and neurological disorders, cardiovascular disease and cancers. Using Caenorhabditis elegans as a model system, I am combining my interests of RNA biology and gene regulation to determine molecular mechanisms underpinning mitochondrial dysfunction.