Jared Nordman
Department of Biological Sciences
Department of Cell and Developmental Biology (CDB)
Vanderbilt-Ingram Cancer Center (VICC)
VICC Genome Maintenance Research Program
Regulation of genome duplication requires exquisite control to ensure proper transmission of genetic material from mother cell to daughter cell and to prevent the genome aberrations that are associated with cancer cells. Importantly, the replication machinery must respond to changes in chromatin structure and cell cycle parameters that are associated with cellular differentiation to maintain genome integrity. We are using a combination of proteomic, genomic, cell biological, genetic and biochemical approaches to uncover and characterize fundamental aspects of genome duplication and stability.
Regulation of genome duplication requires exquisite control to ensure proper transmission of genetic material from mother cell to daughter cell and to prevent the genome aberrations that are associated with cancer cells. Importantly, the replication machinery must respond to changes in chromatin structure and cell cycle parameters that are associated with cellular differentiation to maintain genome integrity. We are using a combination of proteomic, genomic, cell biological, genetic and biochemical approaches to uncover and characterize fundamental aspects of genome duplication and stability.
Keywords: Genome stability , DNA replication , Development , Chromatin , Cell cycle , Drosophila
Research Area: Cell Cycle, DNA Repair, and Chromosome Biology , Genomics , Cancer Biology , Developmental Biology , Proteomics/Metabolomics