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Kate Clowes

University of Kentucky

Chuck Sanders Lab

My research focuses on the potassium channel KCNQ1. Loss of function mutations in KCNQ1 cause Type 1 Long QT Syndrome (LQT1), a heart rhythm disorder that increases risk of arrhythmias and cardiac arrest. I plan to study the effect of LQT1-associated mutations in KCNQ1 on protein stability and trafficking, and develop a method to screen for drugs that restore stability and trafficking of destabilized KCNQ1 mutants.