Chuck Sanders lab
The driving idea behind my project is to use nuclear magnetic resonance (NMR) spectroscopy to probe the interactions between the Amyloid Precursor Protein (APP) and small-molecule drug fragments. APP is a single-pass transmembrane protein which is expressed and processed in the brain to yield Î²-amyloid (Î²A), the hypothesized cause of Alzheimer's disease. The long term goal of this project is to develop a rigorous method for using fragment-based drug design methods on integral membrane proteins relevant to human disease. A relevant side project is to develop novel membrane mimetics that simulate near-biological conditions with implications in structural biology and drug development.