Central Michigan University
Matt Tyska lab
My research is focused on the I-BAR domain containing protein IRTKS and how it is promoting intestinal microvillar growth. It is not yet known how microvilli go from a growing, disorganized state in the intestinal crypts to achieve a uniform length on the intestinal villus. I have found that IRTKS is targeted to the barbed ends of crypt microvillar actin bundles and uses a WH2 domain to help microvilli achieve the length they need to properly function out on the villus.