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Melanie Hurst

University of Kentucky

Maria Hadjifrangiskou lab

Bacteria exist in diverse environmental niches. To do this, they must be able to rapidly respond and adapt to their surroundings. Two-component signal transduction systems (TCSs) allow for signal detection and appropriate bacterial response. My project focuses on the characterization of the interface of cross-interaction between two TCS (PmrAB and QseBC) that mediate virulence in uropathogenic E. coli and determine the molecular mechanisms which drive PmrAB and QseBC.