Richard Peek
Vanderbilt Digestive Diseases Research Center (VDDRC)
Vanderbilt-Ingram Cancer Center (VICC)
Our laboratory is focused on microbially-induced gastric carcinogenesis with the overarching theme being delineation of the signaling events initiated by bacterial:epithelial cell contact that regulate carcinogenic phenotypes using complementary model systems. Our group utilizes ex vivo gastric organoid systems that closely recapitulate cellular organization in the stomach to examine aberrant responses to oncogenic H. pylori strains. We also developed robust and reproducible rodent models of H. pylori-induced gastric cancer and continually extend our observations into human populations.
Our laboratory is focused on microbially-induced gastric carcinogenesis with the overarching theme being delineation of the signaling events initiated by bacterial:epithelial cell contact that regulate carcinogenic phenotypes using complementary model systems. Our group utilizes ex vivo gastric organoid systems that closely recapitulate cellular organization in the stomach to examine aberrant responses to oncogenic H. pylori strains. We also developed robust and reproducible rodent models of H. pylori-induced gastric cancer and continually extend our observations into human populations.
Keywords: Carcinogenesis , Helicobacter pylori , Gastric Cancer , Stem Cell responses to pathogens , Inflammation-induced malignancies
Research Area: Host-Pathogen Interactions , Stem Cell Biology & Regeneration , Bacteriology , Cancer Biology , Cell Signaling