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Sara Kassel

Marquette University

Ethan Lee lab

Thyroid Hormone Receptor-Interacting Protein 12 (Trip12) functions as an E3 ubiquitin-protein ligase. Recent studies indicate that Trip12 may play a role in the Wnt pathway. Wnt signaling is known to be important during development and is frequently mutated in cancer. My ongoing graduate research is focused on characterizing the function of Trip12 in the Wnt pathway. I believe the results of my research will provide a better understanding of the basic biology of Wnt signaling and will be relevant to human health by informing on the development of novel therapeutics for Wnt-driven diseases.