Sarah Arcos
Georgetown University
Manny Ascano lab
My project involves the study of post-transcriptional gene regulation in innate immunity. I am currently working on characterizing the role of RNA-binding proteins during innate immune activation, particularly proteins that specifically recognize and bind to N6-methyladenosine (m6A) modified RNA. The methylation of mRNAs at the N6 position of adenosines is a highly conserved chemical modification found in viral genomes to higher eukaryotes, and is thought to play a regulatory role by affecting RNA stability or translation.