Scott Smith
Vanderbilt Vaccine Center (VVC)
Department of Pediatrics; Division of Infectious Diseases
We have established a method to grow, identify and immortalize IgE encoding B cells from peripheral blood of allergic and helminth infected individuals. With this technology we can generate and study, for the first time, naturally-occurring human IgE monoclonal antibodies specific to clinically important allergens and parasitic worms. These studies will provide novel insights into the pathogenesis of allergic diseases for the development of new therapeutics and the natural immunity to helminth infection to assist with the rational design of vaccines.
We have established a method to grow, identify and immortalize IgE encoding B cells from peripheral blood of allergic and helminth infected individuals. With this technology we can generate and study, for the first time, naturally-occurring human IgE monoclonal antibodies specific to clinically important allergens and parasitic worms. These studies will provide novel insights into the pathogenesis of allergic diseases for the development of new therapeutics and the natural immunity to helminth infection to assist with the rational design of vaccines.
Keywords: Monoclonal antibody , Allergy , Immunology , IgE , Vaccinology , Parasitology
Research Area: Immunology