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Slavi Goleva

University of Kentucky

David Sweatt lab

Recent research on epigenetic mechanisms has resulted in a tremendous growth of our understanding of transcriptional regulation across various systems. My research project focuses on investigating how epigenetic mechanisms regulate transcription in functioning neurons. Specifically, it focuses on elucidating how upstream signaling may alter epigenetic mechanisms such as DNA cytosine methylation, and the downstream effects this has on transcription in neurons. I'm also focused on determining if these alterations in DNA methylation are persisting, which could cause long-term changes in transcription. This knowledge can increase our understanding of basic processes such as learning and memory formation, as well as behavioral and physiological abnormalities in-vivo.