Middle Tennessee State University
Ethan Lee lab
Ubiquitin Specific Peptidase 47 (USP47) functions as a deubiquitinase in the Wnt pathway. After the Beta catenin degradation complex is formed, Beta catenin is phosphorylated, priming it for ubiquitination and subsequent degradation. However, USP47 acts to remove the ubiquitin, thus playing a role in Beta catenin stabilization. I want to elucidate the function of USP47 and its involvement in the canonical Wnt-Beta catenin pathway.