MP&B 8327: Molecular Endocrinology
COURSE DESCRIPTION:
MP&B 8327. Molecular Endocrinology. A survey of the molecular biology of hormone action from the target cell surface to the nucleus. Special emphasis on (i) diabetes and obesity and (ii) how receptors and intracellular messengers mediate hormone action, (iii) how hormones regulate gene expression, and (iv) signaling in adipocytes. Discussion of the use of genetic, molecular biology, and biochemical techniques to study hormone action. The faculty encourage an interactive atmosphere in the class through the discussion of seminal papers. This is an advanced course so some prior background in cell signaling is recommended.
COURSE SCHEDULE: Fall 2022
Time: Wednesday, 3-5pm
Location: Eskind Library Room 334
Credit: 2 hours
Information: Call Richard O’Brien at 936-1503/1629
Section 1: O’Brien
| Aug. 25 | Diabetes |
| Sept. 1 | Insulin action – part 1 |
| Sept. 8 | Insulin action – part 2 |
| Sept. 15 | Treatments for type 2 diabetes |
| Sept. 22 | Paper discussion |
| Sept. 29 | Paper discussion |
Section 2: Colbran
| Oct. 6 | Lipolysis: HSL, ATGL, perilipin, and cAMP/PKA signaling |
| Oct. 13 | Lipogenesis: phosphatases and insulin signaling in adipocytes |
| Oct. 20 | AMPK signaling in adipocytes and beyond |
| Oct. 27 | Take home exam |
Section 3: Vickers/Rendina-Ruedy/Ayala
| Nov. 3 | Novel Endocrine-like Communication Networks (Vickers) |
| Nov. 10 | Bone as an Endocrine Tissue (Rendina-Ruedy) |
| Nov. 17 | Lipoprotein Metabolism and Cholesterol Homeostasis (Vickers) |
| Nov. 24 | No lecture – Thanksgiving |
| Dec. 1 | Central Regulation of Energy Balance (Ayala) |
| Dec. 8 | Take home exam |