The Department of Molecular Physiology and Biophysics (MPB) is a basic science department in the Vanderbilt University School of Medicine. The department has been consistently ranked in the top three physiology departments in the nation based on funding from the National Institutes of Health, as well NRC ranking of related graduate programs. Faculty in the department use diverse cutting edge techniques to address important research questions that span the spectrum of biomedical sciences.
Recent Notable Papers from MPB labs
David Samuels publishes a paper in Critical Care Medicine: “Mitochondrial DNA Haplogroups and Delirium During Sepsis.”
Mason McClatchey (Wasserman lab) has a first author paper in Diabetes: “Fibrotic Encapsulation Is the Dominant Source of Continuous Glucose Monitor Delays.”
Neuert lab has a paper in Scientific Data: “Multiplex RNA single molecule FISH of inducible mRNAs in single yeast cells.”
Jason Spaeth (Stein Lab) publishes in Diabetes: “The Pdx1 Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β Cell Function.”
Cherrington lab publishes in Diabetes Obesity & Metabolism: “Peripherally Delivered Hepatopreferential Insulin Analog Insulin-406 Mimics the Hypoglycemia-sparing Effect of Portal Vein Human Insulin Infusion in Dogs.”
Reza Dastvan (Mchaourab lab) publishes a paper in Science: “Mechanism of allosteric modulation of P-glycoprotein by transport substrates and inhibitors”
Quan Wang (Bingshan Li’s lab) publishes in Nature Neuroscience: “A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data.”
Guillaume Kraft (Cherrington Lab) pubishes a first author paper in Diabetes: “Sympathetic Denervation of the Common Hepatic Artery Lessens Glucose Intolerance in the Fat and Fructose Fed Dog”
Venters lab publishes in Scientific Data: “Epigenetic and transcriptional profiling of triple negative breast cancer.”
Dale Edgerton and Alan Cherrington published a paper in JCI Insight: “Targeting insulin to the liver corrects defects in glucose metabolism caused by peripheral insulin delivery”
Curtis Hughey was the first author paper in Molecular Metabolism from the Wasserman Lab: “Dysregulated transmethylation leading to hepatocellular carcinoma compromises redox homeostasis and glucose formation”
Galli/Mchaourab labs publish in PNAS: “Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion in SLC6A3”
Rachel Hallyur (Powers lab) published a paper titled “Human islets expressing HNF1A variant have defective β cell transcriptional regulatory networks” in The Journal of Clinical Investigation.
The Journal of Neuroscience published a paper titled “α2A-adrenergic receptor activation decreases parabrachial nucleus excitatory drive onto BNST CRF neurons and reduces their activity in vivo” from the Winder Lab with Tracy Fetterly as the first author.
Stein lab published a paper by Holly Cyphert in Diabetes titled: “Examining How the MAFB Transcription Factor Affects Islet β Cell Function Postnatally“.
Sam Centanni (Winder lab) published a paper in Neuropsychopharmacology titled: “Endocannabinoid control of the insular-bed nucleus of the stria terminalis circuit regulates negative affective behavior associated with alcohol abstinence”
Arion Kennedy (Research Assistant Professor) publishes a paper titled “High CD8 T Cell Receptor Clonality and Altered CDR3 Properties are Associated with Elevated Isolevuglandins in Adipose Tissue During Diet-Induced Obesity” in Diabetes
The Journal of Neuroscience published a paper by Nick Harris (MSTP student in the Winder Lab) titled: “Dorsal BNST α2A-adrenergic receptors produce HCN-dependent excitatory actions that initiate anxiogenic behaviors“.
Cherrington lab published a paper entitled “Enterically delivered insulin tregopil exhibits rapid absorption characteristics and a pharmacodynamic effect similar to human insulin in conscious dogs” in Diabetes, Obesity and Metabolism.
Ian Williams, a graduate student in the Wasserman lab, published in Diabetes: “Acute Nitric Oxide Synthase Inhibition Accelerates Trans-Endothelial Insulin Efflux in Vivo” in Diabetes”
Oliver Vranjkovic (Winder lab) publishes in Neuropsychopharmacology: “Ketamine administration during a critical period after forced ethanol abstinence inhibits the development of time-dependent affective disturbances”
Claxton & Mchaourab publish in PNAS: “Sodium and proton coupling in the conformational cycle of a MATE antiporter from Vibrio cholerae”
Neuert lab publishes in PNAS: “Distribution shapes govern the discovery of predictive models for gene regulation”