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The Department of Molecular Physiology and Biophysics (MPB) is a basic science department in the Vanderbilt University School of Medicine. The department has been consistently ranked in the top three physiology departments in the nation based on funding from the National Institutes of Health, as well NRC ranking of related graduate programs. Faculty in the department use diverse cutting edge techniques to address important research questions that span the spectrum of biomedical sciences.

 

Recent Notable papers from MPB labs

Rachel Hallyur (Powers lab) published a paper titled “Human islets expressing HNF1A variant have defective β cell transcriptional regulatory networks”  in The Journal of Clinical Investigation.

The Journal of Neuroscience published a paper titled “α2A-adrenergic receptor activation decreases parabrachial nucleus excitatory drive onto BNST CRF neurons and reduces their activity in vivo” from the Winder Lab with Tracy Fetterly as the first author.

Stein lab published a paper by Holly Cyphert in Diabetes titled: “Examining How the MAFB Transcription Factor Affects Islet β Cell Function Postnatally“.

Sam Centanni (Winder lab) published a paper in Neuropsychopharmacology titled: “Endocannabinoid control of the insular-bed nucleus of the stria terminalis circuit regulates negative affective behavior associated with alcohol abstinence

Arion Kennedy (Research Assistant Professor) publishes a paper titled “High CD8 T Cell Receptor Clonality and Altered CDR3 Properties are Associated with Elevated Isolevuglandins in Adipose Tissue During Diet-Induced Obesity” in Diabetes

The Journal of Neuroscience published a paper by Nick Harris (MSTP student in the Winder Lab) titled: “Dorsal BNST α2A-adrenergic receptors produce HCN-dependent excitatory actions that initiate anxiogenic behaviors“.

Cherrington lab published a paper entitled “Enterically delivered insulin tregopil exhibits rapid absorption characteristics and a pharmacodynamic effect similar to human insulin in conscious dogs” in Diabetes, Obesity and Metabolism.

Ian Williams (MPB student, Wasserman lab) publishes a paper titled “Acute Nitric Oxide Synthase Inhibition Accelerates Trans-Endothelial Insulin Efflux in Vivo” in Diabetes”

Neuropsychopharmacology publishes a paper by Oliver Vranjkovic (Winder lab): “Ketamine administration during a critical period after forced ethanol abstinence inhibits the development of time-dependent affective disturbances”

Claxton and Mchaourab publish “Sodium and proton coupling in the conformational cycle of a MATE antiporter from Vibrio cholerae” in PNAS

PNAS paper published by the Neuert lab: “Distribution shapes govern the discovery of predictive models for gene regulation”

Hasty lab publishes Trends in Pharmacological Sciences review: “Macrophage-Targeted Therapeutics for Metabolic Disease”

Mchaourab co-authors a Nature paper: “Mechanism of NMDA receptor channel block by MK-801 and memantine”

Moore/Cherrington publish in Diabetes (again): “Morning Hyperinsulinemia Primes the Liver for Glucose Uptake and Glycogen Storage Later in the Day”