John (Jack) Walker

John (Jack) Walker

Graduate Student, Powers laboratory, Molecular Physiology & Biophysics


My project focuses on defining the molecular signatures defining islet dysfunction in recent-onset type 2 diabetes in human tissues. To do this, I am characterizing the functional, morphologic, and transcriptional profiles of islets from individuals with type 2 diabetes using a combination of human pancreatic tissue, isolated islets, and sorted islet cell populations. I am also investigating the source of amyloid heterogeneity in type 2 diabetic islets.