Molecular Physiology & Biophysics

Recent observations have challenged long held concepts in the pathophysiology of type 1 diabetes. By implementing an integrative approach to study both the native pancreas and isolated islets from the same human donor, I work to characterize the function and morphology of T1D pancreatic islets using in vitro and in vivo functional studies and immunohistochemistry. My primary project focuses on the glucagon-producing alpha cells in the T1D islet and identifying the mechanisms behind disordered glucagon secretion in T1D.