• Mori T, Mchaourab H, Johnson CH. Circadian Clocks: Unexpected Biochemical Cogs. Current biology : CB. 2015 Oct 5;25(19). R842-4. PMID: 26439342 [PubMed]. PMCID: PMC4697453. NIHMSID: NIHMS744952.


A circadian oscillation can be reconstituted in vitro from three proteins that cycles with a period of ∼ 24 h. Two recent studies provide surprising biochemical answers to why this remarkable oscillator has such a long time constant and how it can switch effortlessly between alternating enzymatic modes.