Growth Hormone Mediates Its Protective Effect in Hepatic Apoptosis through Hnf6.
AUTHORS
Wang
K ,
Wang
M ,
Gannon
M ,
Holterman
A ,
. PloS one. 2016 ; 11(12). e0167085
- PMID: 27936029 [PubMed].
- PMCID: PMC5147851.
ABSTRACT
Growth hormone (GH) not only supports hepatic metabolism but also protects against hepatocyte cell death. Hnf6 (or Oc1) belonging to the Onecut family of hepatocyte transcription factors known to regulate differentiated hepatic function, is a GH-responsive gene. We evaluate if GH mediates Hnf6 activity to attenuate hepatic apoptotic injury.
Growth hormone (GH) not only supports hepatic metabolism but also protects against hepatocyte cell death. Hnf6 (or Oc1) belonging to the Onecut family of hepatocyte transcription factors known to regulate differentiated hepatic function, is a GH-responsive gene. We evaluate if GH mediates Hnf6 activity to attenuate hepatic apoptotic injury.
Tags: 2016