MPH alumni works to uncovers cellular responses to bird flu vaccine
Vanderbilt MPH Program alumna Leigh Howard, M.D., M.P.H., assistant professor of Pediatrics and alumnus Buddy Creech, M.D. collaborated with other members of the team to study a vaccine for bird flu subtype H5N1, which is far more lethal in humans than seasonal flu.
Reported in the journal PLOS One, the study exposes cellular responses associated with a vaccine constituent called AS03, short for adjuvant system 03. Using massive computation, the investigators pursue a systems biology approach, providing a new wealth of detail about vaccine responses and data for the generation of new hypotheses.