Shrubsole’s team identifies new gene candidates for breast cancer risk
An international coalition led by scientists at Vanderbilt University Medical Center and the QIMR Berghofer Medical Research Institute in Herston, Australia, has identified 48 candidate susceptibility genes for breast cancer risk, including 14 genes at loci (chromosome regions) not yet reported for breast cancer.
Their findings, published June 18 in the journal Nature Genetics, provide new insights into the biology and genetics of breast cancer, the most common cancer among women in many countries around the globe.
The functional analyses were led by Georgia Chenevix-Trench, PhD, head of the Cancer Genetics Laboratory at QIMR Berghofer and the paper’s co-corresponding author with Zheng.
Other Vanderbilt faculty members who contributed to the study were Jirong Long, Ph.D., Xingyi Guo, PhD, Xiao-Ou Shu, MD, PhD, MPH, Qiuyin Cai, MD, PhD, Bingshan Li, MD, PhD, and Martha Shrubsole, PhD.
The research was supported in part by National Institutes of Health grants CA158473, CA148677, CA218892 and CA160056.