New Publications
MSTPublications: September 2024
Sep. 27, 2024—Pharmacologic Hedgehog inhibition modulates the cytokine profile of osteolytic breast cancer cells. Bennett NE, Parker DV, Mangano RS, Baum JE, Northcutt LA, Miller JS, Beadle EP, Rhoades JA. J Bone Oncol. 2024 Jul 28;47:100625. doi: 10.1016/j.jbo.2024.100625. eCollection 2024 Aug. The establishment and progression of bone metastatic breast cancer is supported by immunosuppressive myeloid populations that...
MSTPublications: August 2024
Aug. 29, 2024—ER-phagy drives age-onset remodeling of endoplasmic reticulum structure-function and lifespan. Donahue E, Hepowit NL, Keuchel B, Mulligan AG, Johnson DJ, Ellisman M, Arrojo E Drigo R, MacGurn J, Burkewitz K. bioRxiv [Preprint]. 2024 Aug 8:2024.08.07.607085. doi: 10.1101/2024.08.07.607085. The endoplasmic reticulum (ER) comprises an array of structurally distinct subdomains, each with characteristic functions. While altered ER-associated...
MSTPublications: July 2024
Jul. 29, 2024—A transcriptomic atlas of the human brain reveals genetically determined aspects of neuropsychiatric health. Bledsoe X, Gamazon ER. Am J Hum Genet. 2024 Jun 19:S0002-9297(24)00208-8. doi: 10.1016/j.ajhg.2024.06.002. Online ahead of print. Regulation of gene expression is a vital component of neurological homeostasis. Cataloging the consequences of endogenous gene expression on the physical structure and connectivity...
MSTPublications: June 2024
Jun. 27, 2024—The interictal suppression hypothesis is the dominant differentiator of seizure onset zones in focal epilepsy. Doss DJ, Shless JS, Bick SK, Makhoul GS, Negi AS, Bibro CE, Rashingkar R, Gummadavelli A, Chang C, Gallagher MJ, Naftel RP, Reddy SB, Williams-Roberson S, Morgan VL, Johnson GW, Englot DJ. Brain. 2024 Jun 14:awae189. doi: 10.1093/brain/awae189. Online ahead...
MSTPublications: May 2024
May. 30, 2024—Phenomewide Association Study of Health Outcomes Associated With the Genetic Correlates of 25 Hydroxyvitamin D Concentration and Vitamin D Binding Protein Concentration. Kresge HA, Blostein F, Goleva S, Albiñana C, Revez JA, Wray NR, Vilhjálmsson BJ, Zhu Z, McGrath JJ, Davis LK. Twin Res Hum Genet. 2024 Apr 22:1-11. doi: 10.1017/thg.2024.19. Online ahead of print....
MSTPublications: April 2024
Apr. 29, 2024—Solid organ transplant recipients exhibit more TET2-mutant clonal hematopoiesis of indeterminate potential not driven by increased transplantation risk. Silver AJ, Vlasschaert C, Mack T, Sharber B, Xu Y, Bick AG, Pinson CW, Savona MR. Clin Cancer Res. 2024 Mar 29. doi: 10.1158/1078-0432.CCR-23-3840. Online ahead of print. Purpose: Solid organ transplant recipients comprise a unique population...
MSTPublications: March 2024
Mar. 29, 2024—Leveraging generative AI to prioritize drug repurposing candidates for Alzheimer’s disease with real-world clinical validation. Yan C, Grabowska ME, Dickson AL, Li B, Wen Z, Roden DM, Michael Stein C, Embí PJ, Peterson JF, Feng Q, Malin BA, Wei WQ. NPJ Digit Med. 2024 Feb 26;7(1):46. doi: 10.1038/s41746-024-01038-3. Drug repurposing represents an attractive alternative to...
MSTPublications: February 2024
Feb. 29, 2024—Relative predictive value of sociodemographic factors for chronic diseases among All of Us participants: a descriptive analysis. Kunnath AJ, Sack DE, Wilkins CH. BMC Public Health. 2024 Feb 8;24(1):405. doi: 10.1186/s12889-024-17834-1. Background: Although sociodemographic characteristics are associated with health disparities, the relative predictive value of different social and demographic factors remains largely unknown. This study...
MSTPublications: January 2024
Jan. 30, 2024—Approximating Projections of Conformational Boltzmann Distributions with AlphaFold2 Predictions: Opportunities and Limitations. Brown BP, Stein RA, Meiler J, Mchaourab HS. J Chem Theory Comput. 2024 Jan 12. doi: 10.1021/acs.jctc.3c01081. Online ahead of print. Protein thermodynamics is intimately tied to biological function and can enable processes such as signal transduction, enzyme catalysis, and molecular recognition. The...
MSTPublications: December 2023
Dec. 18, 2023—Developing and evaluating pediatric phecodes (Peds-Phecodes) for high-throughput phenotyping using electronic health records. Grabowska ME, Van Driest SL, Robinson JR, Patrick AE, Guardo C, Gangireddy S, Ong HH, Feng Q, Carroll R, Kannankeril PJ, Wei WQ. J Am Med Inform Assoc. 2023 Dec 1:ocad233. doi: 10.1093/jamia/ocad233. Online ahead of print. Objective: Pediatric patients have different...