I use computational modeling and biophysical techniques to understand how proteins interact with their binding partners such as small molecules, peptides, or large proteins. The Meiler Lab actively develops the Rosetta software for protein structure prediction. I complement this software with biophysical techniques such as X-ray crystallography, nuclear magnetic resonance (NMR), and electron paramagnetic resonance (EPR). I have a particular focus on G-protein coupled receptors (GPCRs). I am interested in how ligand binding induces a conformational change in the receptor to lead to activation and signaling through cellular binding proteins such as heterotrimeric G-protein and arrestin.
Graduate Student, Meiler laboratory
BA, Colgate University (2011)