There is currently an unmet need to identify more selective drugs for Slack-induced epilepsies. In order to better understand the role Slack plays in childhood epilepsies we need to develop highly selective molecular probes. When identified, such probes will allow for the investigation of the hypothesis that selective small molecule modulators that normalize inhibitory interneuron based transmission will safely and effectively correct the epileptiform behavior caused by Slack mutations. Discovery and characterization of such compounds will provide a starting point for the development of new clinical tools for the treatment of Slack-induced epilepsies.
Graduate Student, Weaver laboratory
Pharm.D., Lipscomb University(2016)