I study the impacts of secretase inhibition on the trafficking of amyloid precursor protein (APP) and its cleavage products. γ- and β-secretase inhibitors prevent the production of amyloid β from APP and have been investigated as possible treatments for Alzheimer’s disease. However, little is known about the potential consequences of disrupting the amyloidogenic cleavage pathway at the cellular level. I am using a dual-tagged fluorescent APP fusion protein (pH-APP-BFP2) to track APP’s subcellular distribution, endo/exocytosis and cleavage to investigate the effects of α-, β- and γ-secretase inhibitors in live primary neurons. My project aim is to increase understanding of Alzheimer’s disease pathogenesis and aid in the discovery of safer and more selective treatments for Alzheimer’s disease.
Graduate Student, Zhang laboratory
BS, Rhodes College (2011)