Nicole Fisher

Nicole Fisher

Graduate Student, Conn and Niswender laboratories

BS, Miami University (2014)


My project focuses on validating novel treatment strategies for Rett syndrome and MECP2 Duplication syndrome. These are two debilitating neurodevelopmental disorders that are caused by either a loss-of-function mutation or duplication of the MECP2 gene, which codes for the transcriptional regulator Methyl-CpG-Binding Protein 2. We have shown that expression of the metabotropic glutamate receptor 7 (mGlu7) is altered downstream of changes in MECP2 gene dosage. I am particularly interested in understanding how mGlu7 function is altered in these disease contexts and to evaluate the therapeutic potential of fine-tuning mGlu7 activity with small molecule allosteric modulators. To do this, I perform genetic and pharmacological manipulations in mouse models of Rett syndrome and MECP2 Duplication syndrome using a combination of techniques that include biochemistry, brain slice electrophysiology and rodent behavior.