Regulation of neurotransmitter release by activated Gi/o-type G-protein coupled receptors (GPCRs) is of relevance to not only normal brain function and but also to neural disease, such as anxiety, depression, and working memory deficiency disorders. From various known mechanisms, I am particularly interested in Gbg, one of the essential signaling units of activated GPCRs, and their interaction with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE). Using biophysical and biochemical approaches such as a quantitative mass spectrometric targeted multiple reaction monitoring, I intend to elucidate the in vivo expression and localization of neuronal Gb and Gg subunits, and Gbg specificity to auto- and hetero a2a adrenergic receptors and SNARE.
Graduate Student, Hamm laboratory
BS, University of California, San Diego (2010)