2021 VICB Seminar Schedule
Winter-Spring 2021 Seminar Schedule via Zoom
Zoom meeting information will be sent to VICB and CBAS members one week prior to a seminar date. If you have any questions or need more information, please contact Tia Patton at: tia.repscher@vanderbilt.edu
Wednesday, January 13
Kenneth Dawson – UNIVERSITY COLLEGE, DUBLIN
“The Profound Role of the Nanoscale in Biology and Medicine; Perspectives on Modern Bionanoscience”
12:15 P.M. — 1:15 P.M.
Reference Articles:
Mapping protein binding sites on the biomolecular corona of nanoparticles
Classification and biological identity of complex nano shapes
Influence of Size and Shape on the Anatomical Distribution of Endotoxin-Free Gold Nanoparticles
View Kenneth Dawson’s VICB lecture here (VU Net ID/password required).
Wednesday, January 27
Schrodinger Demonstration with Jenny Chambers
Using Molecular Modeling to Advance Chemical Biology Research
12:15 P.M. — 1:15 P.M. Zoom
View the Schrodinger presentation here (VU Net ID/password required).
Wednesday, February 3
Robert Spitale – UNIVERSITY OF CALIFORNIA – IRVINE
Chemical Approaches to Analyzing the Structure of the Transcriptome
12:15 P.M. — 1:15 P.M. Zoom
Wednesday, February 10
Dustin Maly – UNIVERSITY OF WASHINGTON
Allosteric Modulation of Protein Kinases Through Their ATP-Binding Sites
12:15 P.M. — 1:15 P.M. Zoom
Reference Articles:
Chemoproteomic Method for Profiling Inhibitor-Bound Kinase Complexes
A Combined Approach Reveals a Regulatory Mechanism Coupling Src’s Kinase Activity, Localization, and Phosphotransferase-Independent Functions
Parallel Chemoselective Profiling for Mapping Protein Structure
View Dustin Maly’s VICB lecture here (VU Net ID/password required).
Wednesday, February 24
Lyn Jones – DANA FARBER/HARVARD
Target Identification and Validation Using Chemical Biology
12:15 P.M. — 1:15 P.M.
Reference Articles:
Applications of chemogenomic library screening in drug discovery
Rational Targeting of Active-Site Tyrosine Residues Using Sulfonyl Fluoride Probes
Target validation using chemical probes
View Lyn Jones’ VICB lecture here (VU Net ID/password required).
Wednesday, March 3
Wonhwa Cho – UNIVERSITY OF ILLINOIS AT CHICAGO
Lipids & Cancer: New Pathways & Mechanisms
12:15 P.M. — 1:15 P.M. Zoom
References Articles:
Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol
PI 3-Kinase Signaling: AKTing up inside the Cell
Wednesday, March 10
Laura Kiessling – MIT
Glycans in Health and Disease
12:15 P.M. — 1:15 P.M. Zoom
Reference Articles:
Imaging mycobacterial growth and division with a fluorogenic probe
Chemistry-driven glycoscience
Stereoelectronic Effects Impact Glycan Recognition
View Laura Kiessling’s VICB lecture here (VU Net ID/password required).
Wednesday, March 17
Jason Crawford – YALE UNIVERSITY
Decoding metabolism at the host-microbe interface
12:15 P.M. — 1:15 P.M. Zoom
Reference Articles:
Sulfamethoxazole drug stress upregulates antioxidant immunomodulatory metabolites in Escherichia coli
Characterization of Autoinducer-3 Structure and Biosynthesis in E. coli
Structure elucidation of colibactin and its DNA cross-links
View Jason Crawford’s VICB lecture here (VU Net ID/password required).
Wednesday, March 24 VICB’s 500th Speaker!
Michael Marletta – UNIVERSITY OF CALIFORNIA – BERKELEY
Nitric Oxide Signaling: From Prokaryotes to Humans
12:15 P.M. — 1:15 P.M. Zoom
Reference Articles:
Physiological activation and deactivation of soluble guanylate cyclase
Structural Insight into H‐NOX Gas Sensing and Cognate Signaling Protein Regulation
Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy
View Michael Marletta’s VICB lecture here (VU Net ID/password required).
Wednesday, March 31 This seminar is being rescheduled for fall 2021.
Wendy Gordon – UNIVERSITY OF MINNESOTA
Decoding mechanotransduction mechanisms of cell surface receptors
12:15 P.M. — 1:15 P.M. Zoom
Reference Articles:
Enhanced Molecular Tension Sensor Based on Bioluminescence Resonance Energy Transfer (BRET)
A toolkit for studying cell surface shedding of diverse transmembrane receptors
Wednesday, April 7
David Horne – CITY OF HOPE
CD33 CAR T Cell Therapy for (r/r) Acute Myeloid Leukemia
12:15 P.M. — 1:15 P.M. Zoom
Reference Article:
An introduction to chimeric antigen receptor (CAR) T‐cell immunotherapy for human cancer
View David Horne’s VICB lecture here (VU Net ID/password required).
Wednesday, April 14
Joseph Loo – UNIVERSITY OF CALIFORNIA-LOS ANGELES
Mass Spectrometry Au Naturel: A Tool to Impact Brain Health Studies and for Structural Biology
12:15 P.M. — 1:15 P.M. Zoom
Reference Articles:
New astroglial injury-defined biomarkers for neurotrauma assessment
An integrated native mass spectrometry and top-down proteomics method that connects sequence to structure and
function of macromolecular complexes
Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator
View Joseph Loo’s VICB lecture here (VU Net ID/password required).
Wednesday, April 21
Laura Dassama – STANFORD UNIVERSITY
Chemical biology approaches for treating hematologic disorders
12:15 P.M. — 1:15 P.M. Zoom
Wednesday, April 28
Livia Eberlin – UNIVERSITY OF TEXAS AT AUSTIN
Advancing Cancer Research and Patient Care with Mass Spectrometry Technologies
12:15 P.M. — 1:15 P.M. Zoom
Reference Articles:
Performance of the MasSpec Pen for Rapid Diagnosis of Ovarian Cancer
Preoperative metabolic classification of thyroid nodules using mass spectrometry imaging of fine-needle aspiration biopsies
Nondestructive tissue analysis for ex vivo and in vivo cancer diagnosis using a handheld mass spectrometry system
Wednesday, September 15 (In-Person & Zoom)
Vanessa Sperandio – University of Texas-Southwestern, “The Highs and Lows of Enteric Infections”
Research Summary Points:
1) gut-brain axis
2) enteric pathogens
3) inter-kingdom chemical signaling
View the Zoom video of Dr. Sperandio’s presentation.
Wednesday, September 22 (In-Person & Zoom)
Paul Baker – Sciex (In-Person & Zoom), “In-Depth Structural Characterization of Lipids by Electron Activated Dissociation: Redefining Global Lipidomics Analysis”
Research Summary Points:
1) Most current approaches to lipidomics analysis by
mass spectrometry lack structural characterization
of individual lipid molecular species. Rather,
lipids are typically defined with broad
classifications such as sum composition, which
lacks specificity.
2) Electron Impact Excitation of Ions from Organics
(EIEIO) is a novel fragmentation method that
enables complete structural elucidation of lipids,
including the class, fatty acid composition,
location of fatty acids, and the position and
stereochemistry of double bonds in a single
experiment.
3) Using HPLC ESI MS/MS with electron activated
dissociation makes possible the ability to
identify putative lipid biomarkers of human disease
with structural specificity.
View the Zoom video of Dr. Baker’s presentation.
Wednesday, September 29 (Zoom Only)
Mike Waring – Newcastle University
“Approaches to Hit-Finding Using FragLites and Encoded Libraries”
Research Summary Points:
1) FragLites are small, halogenated molecules, smaller than traditional fragments, that express single pharmacophores and can be used to identify productive binding interactions in proteins and to assess ligandability.
2) The utility of FragLites has been demonstrated by mapping interactions with the kinase CDK2 and bromodomains BRD4 and ATAD2.
DNA encoded libraries are an incredibly versatile approach to finding hits, but present a challenge for organic synthesis, we have developed highly efficient methods for synthesising DELs using micellar mediated chemistry.
3) The micellar approach has been used to develop optimised Suzuki and amide couplings to synthesise screening compound on DNA.
View the Zoom video of Dr. Waring’s presentation.
Wednesday, October 6 (In-Person & Zoom)
Milan Mrksich – Northwestern University
“High Throughput Experiments with SAMDI Mass Spectrometry”
Research Summary Points:
1) MALDI mass spectrometry is well-suited for analysis of self-assembled monolayers of alkanethiolates on gold
2) Automation and 1,536 spot plates allow for highthroughput experiments
3) Important applications in drug discovery, identifying enzyme activities and reaction optimization
View the Zoom video of Dr. Mrksich’s presentation.
Wednesday, October 20 (In-Person & Zoom)
Carl Johnson – Vanderbilt University
“What Makes Us Tick? Circadian Adventures From Bacteria to Mammals”
Research Summary Points:
1) What are circadian clocks good for?
2) How does it work in bacteria? Adaptive fitness and mechanism.
3) Drugging the mammalian clock–redox redux.
View the Zoom video of Dr. Johnsons’ presentation.
Wednesday, October 27 (In-Person & Zoom)
Brian Conlon – University of North Carolina, “Overcoming boundaries to improve antibiotic efficacy against Staphylococcus aureus”
Research Summary Points:
1) Biofilms and intracellular S. aureus represent two major antibiotic tolerant niches
during infection
2) Targeting the host cell response can sensitize intracellular S. aureus to antibiotics
3) Anti-persister drugs and novel drug delivery
Wednesday, November 3 (Zoom Only)
Yimon Aye – École Polytechnique Fédérale de Lausanne
“Within Our Control? Elucidating On-Target Reactive Metabolite Signaling”
12:15 P.M. — 1:15 P.M.
Research Overview:
Dr. Aye studies proteins/pathways involved in mammalian genome maintenance and nucleotide signaling, including the mechanisms of anticancer agents in clinical use.
Wednesday, November 10 (In-Person & Zoom)
Jerod Denton – Vanderbilt University Medical Center
“A SWELL time to develop the pharmacology of LRRC8 volume-regulated anion channels”
Research Summary Points:
1) Volume-regulated anion channels (VRAC) encoded by LRRC8 genes play important physiological roles and may represent novel drug targets, however the molecular pharmacology of VRAC comprises weak and non-specific inhibitors.
2) Recent progress toward developing the molecular pharmacology of VRAC sheds new light on the putative regulation of VRAC by leukotriene signaling and oxidative stress.
View the Zoom video of Dr. Dentons’ presentation.
Wednesday, November 17 (In-Person & Zoom)
Jenn Adams, Mike Schribner, Jeff Elich, & Maria McGresham – August Bioservices, “Accelerating pharmaceutical development through efficient Design of Experiments (DoE)” Flyer
Program: The goal of pharmaceutical development is to deliver novel therapies that can significantly improve the lives of patients. Along the drug development pathway there are multiple opportunities to accelerate the development process through thoughtful design of experiments (DoE) and a clear understanding of the regulatory framework. August Bioservices Scientists will discuss the high level milestones of the pharmaceutical development process, focusing on strategies to optimize discovery and increase speed to clinic of confirmed drug candidates.
View the Zoom video of the August Bioservices presentation.
Wednesday, December 1 (Zoom Only)
Rommie Amaro – University of California-San Diego
“Computational Microscopy of SARS-CoV-2”
Research Overview:
Dr. Amaro’s scientific interests lie at the intersection of computer-aided drug discovery and biophysical simulation. Her scientific vision revolves around expanding the range and complexity of molecular constituents represented in such simulations, the development of novel multi-scale methods for elucidating their time dependent dynamics, and the discovery of novel chemical matter controlling biological function.
View the Zoom video of the Dr. Amaro’s presentation.