The ASPIRE Path in Molecular Medicine

My proposed thesis research focuses on characterizing broadly neutralizing antibodies (bnAbs) against Influenza A, with the goal of informing universal vaccine design and therapeutic development. Using techniques such as single B cell sorting, high-throughput sequencing, and structural analysis, I aim to define antibody lineages that target conserved neuraminidase epitopes and to evaluate their neutralization potential across seasonal and pandemic strains. This work aligns closely with APMM’s mission to integrate basic and clinical research. Influenza remains a major public health burden, particularly for immunocompromised and elderly populations. Through clinical mentorship and exposure, I hope to deepen my understanding of how viral evolution, patient immune status, and treatment access shape disease outcomes-knowledge that can directly inform the design of human subject research. As part of the APMM Clinical Project track, I plan to design a study using patient-derived samples (e.g., from vaccine trials or flu-positive individuals) to evaluate antibody responses in real-world settings. By connecting immunological discovery to clinical need, I hope to gain experience translating mechanistic findings into studies that improve prevention and treatment strategies. The APMM will equip me with the mentorship, context, and structure to responsibly integrate human subjects research into my scientific training.