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The ASPIRE Path in Molecular Medicine

Training and Requirements

Mentor Selection

 

To facilitate the seamless integration of the research and clinical aspects of the program each student has an assigned Basic Science Mentor as well as a Clinical Mentor. These two mentors guide students in their choice of didactic courses, clinical seminars and clinician interactions.

Basic Science Mentors: All participating graduate students have already identified their thesis mentor when they matriculate in the program. The thesis adviser also serves as the Basic Science Mentor for the VPMM. Similarly, the research mentor for postdoctoral trainees also serves as the Basic Science Mentor for the VPMM. All full-time basic science tenured and tenure-track faculty members at VUMC are eligible to serve as Basic Science Mentors.

Clinical Mentors: The selection of the Clinical Mentor for each incoming participant is paramount for the success of this program component. The trainee, in consultation with his/her Basic Science Mentor suggests three Clinical Mentors for consideration at the time of application to the VPMM. The Advisory Committee reviews this list and assigns a Clinical Mentor for successful applicants. The clinical mentor is encouraged to participate in thesis or advisory committee meetings during the course of the program, but is not required to be a standing member.

 

Training Requirements

Training requirements for the program consist of the following three major components, all designed to provide a solid grounding in how modern biomedical research impacts a range of disease states:

  • Clinical Contact Hours
  • Didactic Course Work
  • Seminars and Bench-to-Bedside Symposia

Clinical Contact Hours: in order to accommodate social distance requirements during the COIVD epidemic we have created 3 different opportunities for clinical exposure. Students are expected to accumulate a total of 30 hours comprised of any combination of these activities over the course of the 2 year program. These include;

  •  Physician-Patient Interactions in clinical settings [up to 20 hours]. Each student will have an identified clinical mentor who they will meet early on in the program to discuss their interests and opportunities for clinical exposure in different clinical settings at VUMC. Additional clinical contact hours will be provided to interested students by attending the Shade Tree Clinic, a free medical-student-run, physician-supervised clinical resource for uninsured patients.
  • Clinical Case Conference [up to 20 hours]. These are clinical management and/or clinical diagnosis case conferences that are typically given by medical residents and fellows in individual specialty departments at VUMC. Students will be able to find out about these from their clinical mentor.
  • Simulated Patient Interviews [up to 10 contact hours]. The Center for Experiential Learning and Assessment [CELA] at Vanderbilt provides students with the opportunity to interview trained actors who simulate clinical conditions that commonly occur in practice. This provides VPMM students with the unique opportunity to experience the process of clinical assessment and evaluation of patients. After each interview students undergo a feedback session with faculty mentors who will go over their clinical finding, differential diagnosis, and management plans for a patient with this condition.
  • NIH Demystifying Medicine Series [up to 5 contact hours]. This seminar series is jointly sponsored by FAES and NIH, and includes presentations on pathology, diagnosis, and therapy in the context of major disease problems and current research. Primarily directed toward PhD students, clinicians and program managers, this series is designed to help bridge the gap between advances in biology and their application to major human diseases. Each session includes clinical and basic science components presented by NIH staff and invitees. You can attend seminars in real time or watch recorded videos and enter the activity under clinical contact hours in the APMM course management system. For more information and details about the seminar series, visit the website: https://demystifyingmedicine.od.nih.gov/

 

Didactic Courses: This component of the APMM is divided into specific units, usually relating to a specific pathobiology. Most units are a mix of formal presentations as well as opportunities to observe patients or to examine pathologic material. These units vary from semester to semester, are highly flexible and can be custom designed by the trainee, in consultation with the joint mentors, to suit individual requirements, and their selected APMM track (see below). These are:

  • Introduction to Clinical and Translational Research: This is a spring semester IGP module that has been designed to provide a broad introduction to the principals and challenges of human subjects research today. Topics covered include clinical trials, drug development and regulation, bio-repositories and EMR, IRB and ethical considerations, and translational research support and opportunities at Vanderbilt. This is the only required course for all students participating in APMM.
  • Introduction to Clinical Research Methods: This course will use didactic and case-based approach to demonstrate practical tools to facilitate translational research. There will be 12 topics taught each over one-hour blocks coordinated by a basic scientist or physician scientist with experience in translational research. The last session will conclude with student proposals to incorporate a clinical or translational component into their research program using methods discussed in the course. Students will be expected to attend at least 10 mornings of didactic and interactive teaching blocks over the twelve Intro to Clinical Research Methods course. At the end of each session, the course directors will hold a Q&A session to discuss material covered in the session, answer questions students may have. Course directors will attempt to facilitate a connection between the student and clinical researchers at VUMC as appropriate during the course.
  • Human Biology and Disease: The aim of this course is to provide students with a comprehensive, organ-based overview, of human biology and disease pathophysiology from a clinical perspective. There will be 15 disease topics taught over a three week period, each over 2-hour blocks coordinated by a physician or physician scientist involved in treating patients with common diseases affecting different organ systems.

Seminar Series and Bench-to-Bedsides Symposia

  • Program Orientation: All new trainees and their mentors (if possible) attend three weekly orientation meetings in September. These meetings are held to insure that all new members in the program understand all the component parts and their role over the next 2-3 years.
  • Seminar Series: The seminar series meeting is a forum for all participants to discuss progress in the program or to bring up any issues that may have arisen. This is followed either by a research presentation by a trainee, or by an invited speaker. These are typically held on the third Wednesday of the month from 5:00 pm – 6:15 pm in Light Hall 306.
  • Bench-to-Bedside Symposium: The ASPIRE Program in Molecular Medicine has developed the “Bench to Bedside” mini-symposium series as a forum to enhance interaction and discussion between the various Vanderbilt graduate and post-doctoral education programs that are promoting clinical enrichment for basic scientists. The format and topics vary at each meeting but in principal focus around a clinical and basic science topic in the context of a particular disease. These are typically held on the first Wednesday of the month from 5:00 pm – 6:00 pm in Light Hall 419.
  • To meet the requirements, attendance of 70% must be met for the Seminar Series and Bench-to-Beside Series.

 

 

Program Tracks and Timeline

Students can elect to take CORE, Intermediate, or Advanced APMM curriculum tracks, over 2 or 3 year, depending on which track they select.

For more information on APMM tracks, learn more on the Badgr platform. The ASPIRE Path in Molecular Medicine: Advanced Badge awarded to learners who complete the three core components of the APMM program (including the 1-credit hour course, “Introduction to Clinical and Translational Research”) plus an additional four credit hours of courses and a translational research project. Learners may complete credit hours either by registering for-credit or by auditing the course.