DNA Replication

Brandt Eichman and Walter Chazin, professors of biochemistry, worked together to provide a better understanding of how exactly DNA replication is initiated. Their work will influence novel small molecule modifier designs that may serve as tools for detailed studies of DNA replication in cells and eventual therapies. Read More

Combining deep mutagenesis and cryo-EM reveals new conformational state of a protein responsible for high-speed DNA replication. The research builds on growing theories of molecular evolution. Read More

As cells grow and divide, their DNA needs to be accurately replicated and properly segregated to new cells. Errors during replication or segregation can alter the genome and promote cancer. Now, researchers at Vanderbilt University Medical Center have identified the mechanism by which the enzyme and tumor suppressor SETD2 prevents… Read More