Metabolism

Eating breakfast affects how our livers respond to lunch. Research from the Department of Molecular Physiology and Biophysics indicates that this well-known, metabolic memory phenomenon is a result of hormonal interplay and points to critical roles not just for insulin but for glucagon as well. Read More

With a new method, researchers have captured a high-resolution metabolic “map” of how cells orchestrate glucose processing, revealing a hidden world where organelles and molecular complexes collaborate when responding to a rush of nutrients. The results of the pioneering work provide insights into an organizational and molecular framework that can be used to study how metabolic processes are disrupted in diseases and aging. Read More

Physician-scientist Mitch Lazar delivered a School of Medicine Basic Sciences Apex Lecture on Feb. 11 about nuclear receptors and the circadian regulation of metabolism. Read More

Science Immunology study suggests a new class of inborn errors of immunometabolism and could improve care for patients with these complex diseases. Read More

Antentor Hinton Jr. spearheaded a collaboration with labs from across Vanderbilt University, the U.S., and Brazil to create 3D maps of mitochondria inside brown adipose tissue, which may help researchers identify potential therapies to treat metabolic ailments. Read More

Prior to insulin’s introduction to the clinic in 1922, life expectancy after a type 1 diabetes diagnosis was only one to two years. Even after insulin, without the understanding and technology we have today, managing diabetes was a struggle. Read More